Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 528 | 83 | 432 |
| Samples | 484 | 78 | 398 |
| Peptides | 405 | 58 | 346 |
Function
KIF4A · Kinesin family member 4A
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000374403 | O95239 | 528 | 405 |
Gene Properties
Recurrent Mutations
All 405 amino-acid changes on canonical ENST00000374403 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KIF4A · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KIF4A – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Endometrial Carcinoma | 5/42 12% | 34/612 6% |
| Cervical Carcinoma | 2/35 6% | 14/422 3% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Melanoma | 5/210 2% | 55/1899 3% |
| Adrenocortical Carcinoma | 2/3 67% | 1/112 1% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Hodgkins Lymphoma | 0/16 0% | 3/122 2% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 31/1390 2% |
| Colorectal Carcinoma | 7/143 5% | 54/3239 2% |
| Other Solid Cancers | 5/94 5% | 22/1515 1% |
| Gastric Carcinoma | 4/74 5% | 20/1809 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 9/752 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 9/810 1% |
| Breast Carcinoma | 3/144 2% | 33/3264 1% |
| Other Sarcomas | 1/69 1% | 6/699 1% |
| Biliary Tract Carcinoma | 2/54 4% | 7/950 1% |
| Bladder Carcinoma | 3/58 5% | 6/956 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 12/1592 1% |
| Glioma | 4/52 8% | 12/2127 1% |
| Ovarian Carcinoma | 5/109 5% | 3/998 0% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Head and Neck Carcinoma | 1/85 1% | 9/1574 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Neuroendocrine Tumour | 2/154 1% | 2/577 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 12/2550 0% |
| Hepatocellular Carcinoma | 0/46 0% | 12/2210 1% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
Mutation Distribution
Where KIF4A is mutated · all tissues, split by cell line vs tissue
How many mutations in KIF4A were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 528 mutations in KIF4A
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|