Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 217 | 34 | 177 |
| Samples | 186 | 32 | 150 |
| Peptides | 132 | 23 | 112 |
Function
KLK14 · Kallikrein related peptidase 14
This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 16 amino-acid changes on canonical ENST00000156499 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KLK14 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KLK14 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Melanoma | 2/210 1% | 22/1899 1% |
| Endometrial Carcinoma | 1/42 2% | 6/612 1% |
| Bladder Carcinoma | 3/58 5% | 7/956 1% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Colorectal Carcinoma | 6/143 4% | 27/3239 1% |
| Hodgkins Lymphoma | 1/16 6% | 0/122 0% |
| Gastric Carcinoma | 0/74 0% | 13/1809 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Neuroblastoma | 4/87 5% | 4/1331 0% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 9/1390 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Glioma | 0/52 0% | 9/2127 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 3/810 0% |
| Non-Cancerous | 0/104 0% | 3/830 0% |
| Other Solid Cancers | 1/94 1% | 4/1515 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 6/2550 0% |
| Ovarian Carcinoma | 1/109 1% | 1/998 0% |
| Hepatocellular Carcinoma | 0/46 0% | 4/2210 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 2/2534 0% |
| Kidney Carcinoma | 0/85 0% | 3/1862 0% |
| Neuroendocrine Tumour | 1/154 1% | 0/577 0% |
| Other Blood Cancers | 2/61 3% | 2/2725 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| Breast Carcinoma | 2/144 1% | 2/3264 0% |
Mutation Distribution
Where KLK14 is mutated · all tissues, split by cell line vs tissue
How many mutations in KLK14 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 217 mutations in KLK14
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|