Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 830 | 142 | 680 |
| Samples | 230 | 53 | 173 |
| Peptides | 189 | 49 | 148 |
Function
KLK3 · Kallikrein related peptidase 3
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 142 amino-acid changes on canonical ENST00000326003 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KLK3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KLK3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Acute Myeloid Leukemia | 5/90 6% | 0/0 0% |
| Melanoma | 4/210 2% | 38/1899 2% |
| Rhabdomyosarcoma | 0/33 0% | 4/171 2% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 9/810 1% |
| Endometrial Carcinoma | 2/42 5% | 5/612 1% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 9/1390 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Other Sarcomas | 4/69 6% | 2/699 0% |
| Colorectal Carcinoma | 7/143 5% | 17/3239 1% |
| Gastric Carcinoma | 2/74 3% | 11/1809 1% |
| Head and Neck Carcinoma | 0/85 0% | 11/1574 1% |
| Non-Cancerous | 1/104 1% | 5/830 1% |
| Ewings Sarcoma | 2/63 3% | 0/262 0% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Ovarian Carcinoma | 2/109 2% | 3/998 0% |
| Other Solid Cancers | 2/94 2% | 5/1515 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Hepatocellular Carcinoma | 0/46 0% | 9/2210 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 6/1592 0% |
| Glioma | 1/52 2% | 7/2127 0% |
| Prostate Carcinoma | 2/13 15% | 5/2105 0% |
| Kidney Carcinoma | 0/85 0% | 6/1862 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Neuroendocrine Tumour | 2/154 1% | 0/577 0% |
| Neuroblastoma | 3/87 3% | 0/1331 0% |
| Bladder Carcinoma | 0/58 0% | 2/956 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 4/2550 0% |
| Breast Carcinoma | 0/144 0% | 6/3264 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
Mutation Distribution
Where KLK3 is mutated · all tissues, split by cell line vs tissue
How many mutations in KLK3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 50 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 830 mutations in KLK3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|