Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 862 | 121 | 729 |
| Samples | 201 | 57 | 141 |
| Peptides | 177 | 46 | 132 |
Function
KREMEN2 · Kringle containing transmembrane protein 2
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 143 amino-acid changes on canonical ENST00000303746 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KREMEN2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KREMEN2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Neuroendocrine Tumour | 2/154 1% | 5/577 1% |
| Thyroid Gland Carcinoma | 2/45 4% | 12/1592 1% |
| Colorectal Carcinoma | 11/143 8% | 18/3239 1% |
| Head and Neck Carcinoma | 4/85 5% | 10/1574 1% |
| Gastric Carcinoma | 3/74 4% | 11/1809 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 7/1390 0% |
| Other Solid Cancers | 0/94 0% | 11/1515 1% |
| Melanoma | 3/210 1% | 11/1899 1% |
| Biliary Tract Carcinoma | 1/54 2% | 5/950 1% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 14/2550 1% |
| Bladder Carcinoma | 1/58 2% | 4/956 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Endometrial Carcinoma | 3/42 7% | 0/612 0% |
| Ovarian Carcinoma | 3/109 3% | 2/998 0% |
| Cervical Carcinoma | 1/35 3% | 1/422 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 3/810 0% |
| Hepatocellular Carcinoma | 2/46 4% | 4/2210 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Pancreatic Carcinoma | 1/89 1% | 3/1611 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Glioma | 0/52 0% | 4/2127 0% |
| Breast Carcinoma | 1/144 1% | 3/3264 0% |
| Kidney Carcinoma | 1/85 1% | 1/1862 0% |
Mutation Distribution
Where KREMEN2 is mutated · all tissues, split by cell line vs tissue
How many mutations in KREMEN2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 862 mutations in KREMEN2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|