Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 472 | 59 | 408 |
| Samples | 418 | 57 | 357 |
| Peptides | 273 | 32 | 246 |
Function
KRT75 · Keratin 75
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000252245 | O95678 | 472 | 273 |
Gene Properties
Recurrent Mutations
All 273 amino-acid changes on canonical ENST00000252245 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRT75 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRT75 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Melanoma | 3/210 1% | 56/1899 3% |
| Endometrial Carcinoma | 2/42 5% | 14/612 2% |
| Bladder Carcinoma | 0/58 0% | 24/956 3% |
| Hodgkins Lymphoma | 0/16 0% | 3/122 2% |
| Non-Small Cell Lung Carcinoma | 14/304 5% | 20/1390 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 12/810 1% |
| Other Solid Cancers | 2/94 2% | 20/1515 1% |
| Colorectal Carcinoma | 7/143 5% | 38/3239 1% |
| Gastric Carcinoma | 5/74 7% | 20/1809 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 20/1592 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Other Sarcomas | 0/69 0% | 7/699 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Neuroendocrine Tumour | 4/154 3% | 1/577 0% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Hepatocellular Carcinoma | 1/46 2% | 14/2210 1% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 13/2534 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Glioma | 1/52 2% | 11/2127 1% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Breast Carcinoma | 1/144 1% | 15/3264 0% |
| Kidney Carcinoma | 1/85 1% | 8/1862 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
Mutation Distribution
Where KRT75 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRT75 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 15 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 472 mutations in KRT75
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|