Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 201 | 63 | 135 |
| Samples | 188 | 60 | 125 |
| Peptides | 73 | 22 | 55 |
Function
KRTAP1-3 · Keratin associated protein 1-3
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 72 amino-acid changes on canonical ENST00000344363 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP1-3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP1-3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 13/304 4% | 8/1390 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Melanoma | 6/210 3% | 13/1899 1% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 11/1592 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Colorectal Carcinoma | 5/143 4% | 15/3239 0% |
| Biliary Tract Carcinoma | 1/54 2% | 4/950 0% |
| Hepatocellular Carcinoma | 1/46 2% | 10/2210 0% |
| Gastric Carcinoma | 3/74 4% | 6/1809 0% |
| Endometrial Carcinoma | 2/42 5% | 1/612 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 11/2550 0% |
| Pancreatic Carcinoma | 4/89 4% | 3/1611 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 2/810 0% |
| Neuroblastoma | 3/87 3% | 1/1331 0% |
| Prostate Carcinoma | 0/13 0% | 6/2105 0% |
| Other Solid Cancers | 1/94 1% | 3/1515 0% |
| Head and Neck Carcinoma | 1/85 1% | 3/1574 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| Other Blood Cancers | 1/61 2% | 4/2725 0% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 1/2534 0% |
| Neuroendocrine Tumour | 1/154 1% | 0/577 0% |
| Esophageal Carcinoma | 1/23 4% | 0/769 0% |
| Breast Carcinoma | 2/144 1% | 2/3264 0% |
Mutation Distribution
Where KRTAP1-3 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP1-3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 6 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 201 mutations in KRTAP1-3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|