Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 273 | 38 | 232 |
| Samples | 211 | 38 | 170 |
| Peptides | 125 | 19 | 108 |
Function
KRTAP10-10 · Keratin associated protein 10-10
Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000380095 | P60014 | 273 | 125 |
Gene Properties
Recurrent Mutations
All 125 amino-acid changes on canonical ENST00000380095 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP10-10 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP10-10 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Unknown | 0/10 0% | 1/29 3% |
| Melanoma | 3/210 1% | 23/1899 1% |
| Endometrial Carcinoma | 2/42 5% | 6/612 1% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 12/1390 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 19/1592 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 8/810 1% |
| Bladder Carcinoma | 0/58 0% | 11/956 1% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Colorectal Carcinoma | 9/143 6% | 18/3239 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Other Solid Cancers | 1/94 1% | 10/1515 1% |
| Neuroendocrine Tumour | 5/154 3% | 0/577 0% |
| Gastric Carcinoma | 2/74 3% | 9/1809 0% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Non-Cancerous | 0/104 0% | 3/830 0% |
| Hepatocellular Carcinoma | 0/46 0% | 7/2210 0% |
| Head and Neck Carcinoma | 1/85 1% | 4/1574 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Glioma | 0/52 0% | 5/2127 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Other Blood Cancers | 0/61 0% | 6/2725 0% |
| Ovarian Carcinoma | 1/109 1% | 1/998 0% |
| Breast Carcinoma | 3/144 2% | 2/3264 0% |
| Neuroblastoma | 0/87 0% | 2/1331 0% |
| Other Sarcomas | 1/69 1% | 0/699 0% |
| Pancreatic Carcinoma | 0/89 0% | 2/1611 0% |
| Prostate Carcinoma | 0/13 0% | 2/2105 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 2/2550 0% |
Mutation Distribution
Where KRTAP10-10 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP10-10 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 273 mutations in KRTAP10-10
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|