Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 258 | 64 | 193 |
| Samples | 237 | 60 | 176 |
| Peptides | 154 | 32 | 124 |
Function
KRTAP10-11 · Keratin associated protein 10-11
Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000334670 | P60412 | 258 | 154 |
Gene Properties
Recurrent Mutations
All 154 amino-acid changes on canonical ENST00000334670 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP10-11 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP10-11 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Burkitts Lymphoma | 6/32 19% | 0/196 0% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 10/810 1% |
| Endometrial Carcinoma | 1/42 2% | 8/612 1% |
| Melanoma | 6/210 3% | 23/1899 1% |
| Plasma Cell Myeloma | 4/44 9% | 0/305 0% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Cervical Carcinoma | 1/35 3% | 4/422 1% |
| Germ Cell Tumour | 2/25 8% | 0/169 0% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 13/1390 1% |
| Bladder Carcinoma | 1/58 2% | 7/956 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 11/1592 1% |
| Other Sarcomas | 1/69 1% | 4/699 1% |
| Other Solid Cancers | 1/94 1% | 9/1515 1% |
| Glioma | 0/52 0% | 13/2127 1% |
| Neuroendocrine Tumour | 4/154 3% | 0/577 0% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Colorectal Carcinoma | 4/143 3% | 11/3239 0% |
| Non-Cancerous | 0/104 0% | 4/830 0% |
| Hepatocellular Carcinoma | 0/46 0% | 9/2210 0% |
| Gastric Carcinoma | 1/74 1% | 6/1809 0% |
| Ovarian Carcinoma | 2/109 2% | 2/998 0% |
| Head and Neck Carcinoma | 2/85 2% | 3/1574 0% |
| Breast Carcinoma | 2/144 1% | 7/3264 0% |
| Other Blood Cancers | 0/61 0% | 6/2725 0% |
| Neuroblastoma | 2/87 2% | 1/1331 0% |
Mutation Distribution
Where KRTAP10-11 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP10-11 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 258 mutations in KRTAP10-11
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|