Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 315 | 74 | 240 |
| Samples | 269 | 71 | 197 |
| Peptides | 119 | 30 | 93 |
Function
KRTAP10-2 · Keratin associated protein 10-2
This gene encodes a member of the high sulfur-type keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. This gene is located in a cluster of similar genes on 21q22.3. Alternatively-spliced transcript variants have been identified. [provided by RefSeq, Jan 2015].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000391621 | P60368 | 315 | 119 |
Gene Properties
Recurrent Mutations
All 119 amino-acid changes on canonical ENST00000391621 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP10-2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP10-2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Mesothelioma | 0/62 0% | 3/165 2% |
| Biliary Tract Carcinoma | 0/54 0% | 13/950 1% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 10/1390 1% |
| Neuroendocrine Tumour | 5/154 3% | 4/577 1% |
| Melanoma | 3/210 1% | 20/1899 1% |
| Endometrial Carcinoma | 4/42 10% | 3/612 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 15/1592 1% |
| Osteosarcoma | 1/45 2% | 1/166 1% |
| Ewings Sarcoma | 3/63 5% | 0/262 0% |
| Cervical Carcinoma | 1/35 3% | 3/422 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Non-Cancerous | 0/104 0% | 8/830 1% |
| Colorectal Carcinoma | 1/143 1% | 26/3239 1% |
| Other Solid Cancers | 1/94 1% | 10/1515 1% |
| Hepatocellular Carcinoma | 3/46 7% | 11/2210 0% |
| Bladder Carcinoma | 1/58 2% | 5/956 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Gastric Carcinoma | 1/74 1% | 9/1809 0% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 3/810 0% |
| Glioma | 0/52 0% | 9/2127 0% |
| Meningioma | 1/3 33% | 0/252 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 8/2534 0% |
| Esophageal Carcinoma | 1/23 4% | 2/769 0% |
| Ovarian Carcinoma | 3/109 3% | 1/998 0% |
Mutation Distribution
Where KRTAP10-2 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP10-2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 3 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 315 mutations in KRTAP10-2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|