Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 406 | 100 | 300 |
| Samples | 318 | 73 | 241 |
| Peptides | 231 | 49 | 193 |
Function
KRTAP10-4 · Keratin associated protein 10-4
This is an intronless gene located in a cluster of related genes on the q arm of chromosome 21. The proteins encoded by these genes form disulfide bonds with cysteine residues in hair keratins, thereby contributing to the structure and stability of hair fibers. [provided by RefSeq, Apr 2014].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000400374 | P60372 | 406 | 231 |
Gene Properties
Recurrent Mutations
All 231 amino-acid changes on canonical ENST00000400374 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP10-4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP10-4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Acute Myeloid Leukemia | 5/90 6% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 7/133 5% |
| Glioblastoma | 5/98 5% | 0/0 0% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 17/304 6% | 16/1390 1% |
| Osteosarcoma | 3/45 7% | 1/166 1% |
| Endometrial Carcinoma | 2/42 5% | 10/612 2% |
| Melanoma | 3/210 1% | 30/1899 2% |
| Squamous Cell Lung Carcinoma | 6/57 11% | 7/810 1% |
| Burkitts Lymphoma | 3/32 9% | 0/196 0% |
| Gastric Carcinoma | 4/74 5% | 18/1809 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 16/1592 1% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Plasma Cell Myeloma | 1/44 2% | 2/305 1% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 19/2534 1% |
| Other Solid Cancers | 2/94 2% | 10/1515 1% |
| Bladder Carcinoma | 1/58 2% | 6/956 1% |
| Neuroendocrine Tumour | 5/154 3% | 0/577 0% |
| Colorectal Carcinoma | 1/143 1% | 22/3239 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Head and Neck Carcinoma | 2/85 2% | 8/1574 1% |
| Non-Cancerous | 1/104 1% | 4/830 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Hepatocellular Carcinoma | 0/46 0% | 10/2210 0% |
| Biliary Tract Carcinoma | 1/54 2% | 3/950 0% |
| Breast Carcinoma | 1/144 1% | 12/3264 0% |
| Kidney Carcinoma | 1/85 1% | 5/1862 0% |
| Other Blood Cancers | 1/61 2% | 7/2725 0% |
| Neuroblastoma | 0/87 0% | 4/1331 0% |
Mutation Distribution
Where KRTAP10-4 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP10-4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 1 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 406 mutations in KRTAP10-4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|