Stats by Source
Total, split by cell line vs tissue samples
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell lines | Tissue samples | |
|---|---|---|---|
| Mutations | 383 | 87 | 296 |
| Samples | 326 | 76 | 250 |
| Peptides | 163 | 41 | 122 |
Function
KRTAP10-6 · Keratin associated protein 10-6
Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000400368 | P60371 | 383 | 163 |
Gene Properties
Recurrent Mutations
All 163 amino-acid changes on canonical ENST00000400368 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP10-6 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP10-6 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 19/304 6% | 19/1390 1% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Neuroendocrine Tumour | 7/154 5% | 4/577 1% |
| Rhabdomyosarcoma | 0/33 0% | 3/171 2% |
| Melanoma | 5/210 2% | 25/1899 1% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 30/2534 1% |
| Cervical Carcinoma | 0/35 0% | 5/422 1% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 5/810 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Biliary Tract Carcinoma | 0/54 0% | 10/950 1% |
| Ovarian Carcinoma | 4/109 4% | 7/998 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 15/1592 1% |
| Endometrial Carcinoma | 2/42 5% | 4/612 1% |
| Small Cell Lung Carcinoma | 1/9 11% | 6/752 1% |
| Other Solid Cancers | 6/94 6% | 8/1515 1% |
| Other Blood Cancers | 0/61 0% | 20/2725 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Colorectal Carcinoma | 5/143 4% | 19/3239 1% |
| Bladder Carcinoma | 1/58 2% | 5/956 1% |
| Non-Cancerous | 1/104 1% | 4/830 0% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Hepatocellular Carcinoma | 0/46 0% | 10/2210 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Glioma | 2/52 4% | 7/2127 0% |
| Gastric Carcinoma | 1/74 1% | 6/1809 0% |
| Pancreatic Carcinoma | 4/89 4% | 2/1611 0% |
| Head and Neck Carcinoma | 0/85 0% | 5/1574 0% |
Mutation Distribution
Where KRTAP10-6 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP10-6 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 1 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 383 mutations in KRTAP10-6
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|