Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 175 | 69 | 105 |
| Samples | 173 | 69 | 103 |
| Peptides | 74 | 9 | 66 |
Function
KRTAP19-5 · Keratin associated protein 19-5
Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000334151 | Q3LI72 | 175 | 74 |
Gene Properties
Recurrent Mutations
All 74 amino-acid changes on canonical ENST00000334151 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP19-5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP19-5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chordoma | 1/7 14% | 0/13 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 11/1390 1% |
| Non-Cancerous | 10/104 10% | 1/830 0% |
| Chondrosarcoma | 0/14 0% | 1/75 1% |
| Rhabdomyosarcoma | 2/33 6% | 0/171 0% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Endometrial Carcinoma | 1/42 2% | 5/612 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 4/810 0% |
| Bladder Carcinoma | 2/58 3% | 5/956 1% |
| Neuroendocrine Tumour | 2/154 1% | 3/577 1% |
| Gastric Carcinoma | 0/74 0% | 12/1809 1% |
| Melanoma | 4/210 2% | 8/1899 0% |
| Colorectal Carcinoma | 3/143 2% | 14/3239 0% |
| Other Solid Cancers | 3/94 3% | 5/1515 0% |
| Ovarian Carcinoma | 5/109 5% | 0/998 0% |
| Other Sarcomas | 2/69 3% | 1/699 0% |
| Kidney Carcinoma | 0/85 0% | 7/1862 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Pancreatic Carcinoma | 2/89 2% | 3/1611 0% |
| Other Blood Cancers | 2/61 3% | 5/2725 0% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 3/2534 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 5/2550 0% |
| B-Lymphoblastic Leukemia | 3/55 5% | 1/2640 0% |
| Hepatocellular Carcinoma | 0/46 0% | 3/2210 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| Head and Neck Carcinoma | 2/85 2% | 0/1574 0% |
| Biliary Tract Carcinoma | 1/54 2% | 0/950 0% |
Mutation Distribution
Where KRTAP19-5 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP19-5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 175 mutations in KRTAP19-5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|