Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 163 | 31 | 130 |
| Samples | 159 | 31 | 126 |
| Peptides | 62 | 8 | 56 |
Function
KRTAP4-2 · Keratin associated protein 4-2
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000377726 | Q9BYR5 | 162 | 61 |
| ENST00000709608 | A0AAG2UW37* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 61 amino-acid changes on canonical ENST00000377726 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP4-2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP4-2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Esophageal Carcinoma | 0/23 0% | 18/769 2% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Hepatocellular Carcinoma | 0/46 0% | 22/2210 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Melanoma | 7/210 3% | 10/1899 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 5/1390 0% |
| Neuroendocrine Tumour | 5/154 3% | 0/577 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 4/810 0% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Endometrial Carcinoma | 1/42 2% | 2/612 0% |
| Pancreatic Carcinoma | 0/89 0% | 7/1611 0% |
| Bladder Carcinoma | 1/58 2% | 3/956 0% |
| Other Solid Cancers | 1/94 1% | 5/1515 0% |
| Ovarian Carcinoma | 1/109 1% | 3/998 0% |
| Colorectal Carcinoma | 0/143 0% | 12/3239 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Head and Neck Carcinoma | 1/85 1% | 4/1574 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Other Blood Cancers | 0/61 0% | 6/2725 0% |
| Gastric Carcinoma | 0/74 0% | 4/1809 0% |
| Glioma | 0/52 0% | 4/2127 0% |
| Neuroblastoma | 1/87 1% | 1/1331 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 2/1592 0% |
| Non-Cancerous | 0/104 0% | 1/830 0% |
| Breast Carcinoma | 0/144 0% | 3/3264 0% |
| Prostate Carcinoma | 0/13 0% | 1/2105 0% |
Mutation Distribution
Where KRTAP4-2 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP4-2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 1 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 163 mutations in KRTAP4-2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|