Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 165 | 27 | 138 |
| Samples | 154 | 27 | 127 |
| Peptides | 78 | 15 | 65 |
Function
KRTAP9-8 · Keratin associated protein 9-8
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000254072 | Q9BYQ0 | 165 | 78 |
Gene Properties
Recurrent Mutations
All 78 amino-acid changes on canonical ENST00000254072 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP9-8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP9-8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chordoma | 0/7 0% | 1/13 8% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 34/2534 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 7/1390 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 6/810 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Neuroendocrine Tumour | 5/154 3% | 0/577 0% |
| Endometrial Carcinoma | 1/42 2% | 3/612 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Melanoma | 0/210 0% | 8/1899 0% |
| Gastric Carcinoma | 1/74 1% | 6/1809 0% |
| Ovarian Carcinoma | 0/109 0% | 4/998 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Neuroblastoma | 1/87 1% | 3/1331 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 6/2550 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Head and Neck Carcinoma | 3/85 4% | 1/1574 0% |
| Glioma | 0/52 0% | 5/2127 0% |
| Other Blood Cancers | 0/61 0% | 6/2725 0% |
| Other Solid Cancers | 0/94 0% | 3/1515 0% |
| Pancreatic Carcinoma | 1/89 1% | 2/1611 0% |
| Colorectal Carcinoma | 1/143 1% | 5/3239 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
| Thyroid Gland Carcinoma | 1/45 2% | 1/1592 0% |
| Biliary Tract Carcinoma | 0/54 0% | 1/950 0% |
Mutation Distribution
Where KRTAP9-8 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP9-8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 165 mutations in KRTAP9-8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|