Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,243 | 566 | 1,639 |
| Samples | 1,751 | 457 | 1,267 |
| Peptides | 1,481 | 358 | 1,159 |
Function
LAMA5 · Laminin subunit alpha 5
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000252999 | O15230 | 2,243 | 1,481 |
Gene Properties
Recurrent Mutations
All 1481 amino-acid changes on canonical ENST00000252999 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in LAMA5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in LAMA5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 13/40 32% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 5/26 19% | 0/0 0% |
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| Chordoma | 2/7 29% | 1/13 8% |
| Glioblastoma | 11/98 11% | 0/0 0% |
| Melanoma | 39/210 19% | 174/1899 9% |
| Endometrial Carcinoma | 20/42 48% | 44/612 7% |
| Oral Cavity Carcinoma | 5/54 9% | 0/0 0% |
| Acute Myeloid Leukemia | 7/90 8% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 53/304 17% | 73/1390 5% |
| Colorectal Carcinoma | 43/143 30% | 201/3239 6% |
| Gastric Carcinoma | 16/74 22% | 99/1809 5% |
| Cervical Carcinoma | 7/35 20% | 19/422 4% |
| Thymic Epithelial Tumor | 0/0 0% | 2/39 5% |
| Other Solid Cancers | 7/94 7% | 70/1515 5% |
| Squamous Cell Lung Carcinoma | 9/57 16% | 32/810 4% |
| Germ Cell Tumour | 6/25 24% | 3/169 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Neuroendocrine Tumour | 27/154 18% | 5/577 1% |
| Other Sarcomas | 9/69 13% | 20/699 3% |
| Hodgkins Lymphoma | 3/16 19% | 2/122 2% |
| Thyroid Gland Carcinoma | 9/45 20% | 46/1592 3% |
| Bladder Carcinoma | 3/58 5% | 31/956 3% |
| Small Cell Lung Carcinoma | 4/9 44% | 21/752 3% |
| Ovarian Carcinoma | 20/109 18% | 16/998 2% |
| Non-Cancerous | 5/104 5% | 24/830 3% |
| Hepatocellular Carcinoma | 9/46 20% | 59/2210 3% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 74/2550 3% |
| Ewings Sarcoma | 8/63 13% | 1/262 0% |
| Biliary Tract Carcinoma | 1/54 2% | 26/950 3% |
Mutation Distribution
Where LAMA5 is mutated · all tissues, split by cell line vs tissue
How many mutations in LAMA5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,243 mutations in LAMA5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|