Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 602 | 82 | 498 |
| Samples | 301 | 49 | 240 |
| Peptides | 241 | 41 | 200 |
Function
LCK · LCK proto-oncogene, Src family tyrosine kinase
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000336890 | P06239 | 318 | 224 |
| ENST00000333070 | P06239-3 | 283 | 214 |
| ENST00000495610 | A0ACM8QMS7* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 224 amino-acid changes on canonical ENST00000336890 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in LCK · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in LCK – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 9/40 22% | 0/0 0% |
| Melanoma | 3/210 1% | 49/1899 3% |
| Endometrial Carcinoma | 3/42 7% | 12/612 2% |
| Burkitts Lymphoma | 0/32 0% | 4/196 2% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 11/810 1% |
| Colorectal Carcinoma | 13/143 9% | 30/3239 1% |
| Other Solid Cancers | 0/94 0% | 17/1515 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 8/752 1% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 13/1390 1% |
| Gastric Carcinoma | 1/74 1% | 17/1809 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Non-Cancerous | 1/104 1% | 7/830 1% |
| Neuroendocrine Tumour | 0/154 0% | 5/577 1% |
| Biliary Tract Carcinoma | 0/54 0% | 6/950 1% |
| Bladder Carcinoma | 2/58 3% | 4/956 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Head and Neck Carcinoma | 1/85 1% | 6/1574 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Breast Carcinoma | 3/144 2% | 8/3264 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 5/2550 0% |
| Ovarian Carcinoma | 1/109 1% | 2/998 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Pancreatic Carcinoma | 1/89 1% | 3/1611 0% |
| Neuroblastoma | 2/87 2% | 1/1331 0% |
Mutation Distribution
Where LCK is mutated · all tissues, split by cell line vs tissue
How many mutations in LCK were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 602 mutations in LCK
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|