Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 774 | 84 | 675 |
| Samples | 219 | 33 | 179 |
| Peptides | 175 | 23 | 147 |
Function
LGMN · Legumain
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 157 amino-acid changes on canonical ENST00000334869 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in LGMN · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in LGMN – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 1/42 2% | 13/612 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Rhabdomyosarcoma | 0/33 0% | 3/171 2% |
| Colorectal Carcinoma | 8/143 6% | 31/3239 1% |
| Melanoma | 1/210 0% | 22/1899 1% |
| Germ Cell Tumour | 2/25 8% | 0/169 0% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 12/1390 1% |
| Other Solid Cancers | 0/94 0% | 14/1515 1% |
| Non-Cancerous | 2/104 2% | 6/830 1% |
| Gastric Carcinoma | 0/74 0% | 16/1809 1% |
| Neuroendocrine Tumour | 4/154 3% | 1/577 0% |
| Cervical Carcinoma | 2/35 6% | 1/422 0% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Bladder Carcinoma | 2/58 3% | 4/956 0% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 3/810 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Pancreatic Carcinoma | 2/89 2% | 3/1611 0% |
| Ovarian Carcinoma | 1/109 1% | 2/998 0% |
| Head and Neck Carcinoma | 0/85 0% | 4/1574 0% |
| Wilms Tumour | 0/5 0% | 1/474 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 4/2534 0% |
| Prostate Carcinoma | 0/13 0% | 4/2105 0% |
| Breast Carcinoma | 0/144 0% | 6/3264 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 4/2550 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
Mutation Distribution
Where LGMN is mutated · all tissues, split by cell line vs tissue
How many mutations in LGMN were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 774 mutations in LGMN
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|