Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 357 | 28 | 324 |
| Samples | 173 | 19 | 151 |
| Peptides | 135 | 13 | 123 |
Function
LIN28B · Lin-28 RNA binding posttranscriptional regulator B
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000345080 | Q6ZN17 | 184 | 130 |
| ENST00000637759 | A0A1B0GVD3* | 172 | 125 |
| ENST00000635857 | A0A1B0GTK2* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 130 amino-acid changes on canonical ENST00000345080 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in LIN28B · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in LIN28B – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 5/210 2% | 32/1899 2% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 9/810 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Other Solid Cancers | 0/94 0% | 16/1515 1% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 9/1390 1% |
| Endometrial Carcinoma | 1/42 2% | 3/612 0% |
| Head and Neck Carcinoma | 0/85 0% | 9/1574 1% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Colorectal Carcinoma | 4/143 3% | 11/3239 0% |
| Gastric Carcinoma | 0/74 0% | 8/1809 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 9/2550 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Glioma | 0/52 0% | 7/2127 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Kidney Carcinoma | 4/85 5% | 2/1862 0% |
| Neuroendocrine Tumour | 0/154 0% | 2/577 0% |
| Ovarian Carcinoma | 0/109 0% | 3/998 0% |
| Breast Carcinoma | 0/144 0% | 9/3264 0% |
| Pancreatic Carcinoma | 0/89 0% | 4/1611 0% |
| Biliary Tract Carcinoma | 0/54 0% | 2/950 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 1/2534 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 1/1592 0% |
| Prostate Carcinoma | 0/13 0% | 1/2105 0% |
| Other Blood Cancers | 0/61 0% | 1/2725 0% |
Mutation Distribution
Where LIN28B is mutated · all tissues, split by cell line vs tissue
How many mutations in LIN28B were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 17 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 357 mutations in LIN28B
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|