Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 687 | 117 | 559 |
| Samples | 354 | 77 | 272 |
| Peptides | 286 | 49 | 243 |
Function
LONP2 · Lon peptidase 2, peroxisomal
In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 279 amino-acid changes on canonical ENST00000285737 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in LONP2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in LONP2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 16/612 3% |
| Hodgkins Lymphoma | 4/16 25% | 0/122 0% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Melanoma | 5/210 2% | 34/1899 2% |
| Gastric Carcinoma | 4/74 5% | 30/1809 2% |
| Colorectal Carcinoma | 9/143 6% | 46/3239 1% |
| Cervical Carcinoma | 2/35 6% | 5/422 1% |
| Bladder Carcinoma | 2/58 3% | 13/956 1% |
| Burkitts Lymphoma | 2/32 6% | 1/196 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 11/810 1% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 12/1390 1% |
| Ovarian Carcinoma | 8/109 7% | 2/998 0% |
| Plasma Cell Myeloma | 2/44 5% | 1/305 0% |
| Neuroendocrine Tumour | 6/154 4% | 0/577 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Hepatocellular Carcinoma | 0/46 0% | 15/2210 1% |
| Non-Cancerous | 1/104 1% | 5/830 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 14/2550 1% |
| Biliary Tract Carcinoma | 3/54 6% | 3/950 0% |
| Kidney Carcinoma | 2/85 2% | 9/1862 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 9/1592 1% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Other Sarcomas | 0/69 0% | 4/699 1% |
| Head and Neck Carcinoma | 1/85 1% | 7/1574 0% |
| Breast Carcinoma | 0/144 0% | 11/3264 0% |
| Other Solid Cancers | 1/94 1% | 4/1515 0% |
| B-Cell Non-Hodgkins Lymphoma | 4/88 5% | 3/2534 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Prostate Carcinoma | 3/13 23% | 2/2105 0% |
Mutation Distribution
Where LONP2 is mutated · all tissues, split by cell line vs tissue
How many mutations in LONP2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 687 mutations in LONP2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|