Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,772 | 511 | 2,217 |
| Samples | 1,859 | 341 | 1,493 |
| Peptides | 1,716 | 289 | 1,451 |
Function
LRP1 · LDL receptor related protein 1
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 1700 amino-acid changes on canonical ENST00000243077 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in LRP1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in LRP1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 19/40 48% | 0/0 0% |
| Endometrial Carcinoma | 19/42 45% | 78/612 13% |
| Melanoma | 23/210 11% | 172/1899 9% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 51/304 17% | 75/1390 5% |
| Hodgkins Lymphoma | 4/16 25% | 6/122 5% |
| Colorectal Carcinoma | 41/143 29% | 201/3239 6% |
| Gastric Carcinoma | 15/74 20% | 115/1809 6% |
| Other Solid Cancers | 12/94 13% | 90/1515 6% |
| Glioblastoma | 6/98 6% | 0/0 0% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Bladder Carcinoma | 6/58 10% | 49/956 5% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 44/810 5% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Neuroendocrine Tumour | 15/154 10% | 16/577 3% |
| Ovarian Carcinoma | 15/109 14% | 29/998 3% |
| Cervical Carcinoma | 1/35 3% | 17/422 4% |
| Small Cell Lung Carcinoma | 2/9 22% | 26/752 3% |
| Head and Neck Carcinoma | 6/85 7% | 49/1574 3% |
| Esophageal Carcinoma | 0/23 0% | 26/769 3% |
| Hepatocellular Carcinoma | 5/46 11% | 67/2210 3% |
| Esophageal Squamous Cell Carcinoma | 7/51 14% | 65/2550 3% |
| Biliary Tract Carcinoma | 6/54 11% | 21/950 2% |
| Other Sarcomas | 6/69 9% | 14/699 2% |
| Germ Cell Tumour | 2/25 8% | 3/169 2% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Non-Cancerous | 1/104 1% | 22/830 3% |
| Ewings Sarcoma | 4/63 6% | 4/262 2% |
| Osteosarcoma | 2/45 4% | 3/166 2% |
Mutation Distribution
Where LRP1 is mutated · all tissues, split by cell line vs tissue
How many mutations in LRP1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,772 mutations in LRP1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|