Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 6,453 | 1,130 | 5,243 |
| Samples | 4,389 | 744 | 3,587 |
| Peptides | 4,143 | 666 | 3,633 |
Function
LRP1B · LDL receptor related protein 1B
This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000389484 | Q9NZR2 | 6,453 | 4,143 |
Gene Properties
Recurrent Mutations
All 2500 amino-acid changes on canonical ENST00000389484 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in LRP1B · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in LRP1B – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 14/40 35% | 0/0 0% |
| Melanoma | 74/210 35% | 520/1899 27% |
| Squamous Cell Lung Carcinoma | 24/57 42% | 216/810 27% |
| Non-Small Cell Lung Carcinoma | 131/304 43% | 331/1390 24% |
| T-Cell Non-Hodgkins Lymphoma | 7/26 27% | 0/0 0% |
| Small Cell Lung Carcinoma | 5/9 56% | 132/752 18% |
| Gastric Carcinoma | 25/74 34% | 310/1809 17% |
| Oral Cavity Carcinoma | 9/54 17% | 0/0 0% |
| Neuroendocrine Tumour | 75/154 49% | 46/577 8% |
| Endometrial Carcinoma | 19/42 45% | 87/612 14% |
| Hodgkins Lymphoma | 6/16 38% | 15/122 12% |
| Glioblastoma | 12/98 12% | 0/0 0% |
| Other Solid Cancers | 12/94 13% | 185/1515 12% |
| Acute Myeloid Leukemia | 11/90 12% | 0/0 0% |
| Colorectal Carcinoma | 57/143 40% | 329/3239 10% |
| Esophageal Carcinoma | 2/23 9% | 87/769 11% |
| Esophageal Squamous Cell Carcinoma | 15/51 29% | 220/2550 9% |
| Head and Neck Carcinoma | 14/85 16% | 129/1574 8% |
| Cervical Carcinoma | 1/35 3% | 38/422 9% |
| Bladder Carcinoma | 16/58 28% | 69/956 7% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Plasma Cell Myeloma | 10/44 23% | 14/305 5% |
| Hepatocellular Carcinoma | 7/46 15% | 138/2210 6% |
| Other Sarcomas | 17/69 25% | 32/699 5% |
| Biliary Tract Carcinoma | 9/54 17% | 52/950 5% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 8/133 6% |
| Rhabdomyosarcoma | 3/33 9% | 9/171 5% |
| Germ Cell Tumour | 5/25 20% | 6/169 4% |
| B-Cell Non-Hodgkins Lymphoma | 26/88 30% | 119/2534 5% |
| Burkitts Lymphoma | 12/32 38% | 0/196 0% |
Mutation Distribution
Where LRP1B is mutated · all tissues, split by cell line vs tissue
How many mutations in LRP1B were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 6,453 mutations in LRP1B
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|