Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,650 | 435 | 2,175 |
| Samples | 1,555 | 292 | 1,232 |
| Peptides | 1,326 | 212 | 1,136 |
Function
LRRK2 · Leucine rich repeat kinase 2
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 1319 amino-acid changes on canonical ENST00000298910 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in LRRK2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in LRRK2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 16/42 38% | 64/612 10% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 82/810 10% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Melanoma | 24/210 11% | 128/1899 7% |
| Gastric Carcinoma | 15/74 20% | 119/1809 7% |
| Non-Small Cell Lung Carcinoma | 37/304 12% | 63/1390 5% |
| Bladder Carcinoma | 3/58 5% | 56/956 6% |
| Colorectal Carcinoma | 36/143 25% | 156/3239 5% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 7/133 5% |
| Small Cell Lung Carcinoma | 0/9 0% | 34/752 5% |
| Neuroendocrine Tumour | 26/154 17% | 5/577 1% |
| Other Solid Cancers | 2/94 2% | 65/1515 4% |
| Glioblastoma | 4/98 4% | 0/0 0% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Cervical Carcinoma | 2/35 6% | 15/422 4% |
| Ovarian Carcinoma | 10/109 9% | 31/998 3% |
| Head and Neck Carcinoma | 11/85 13% | 49/1574 3% |
| Hodgkins Lymphoma | 4/16 25% | 1/122 1% |
| Germ Cell Tumour | 4/25 16% | 3/169 2% |
| Esophageal Carcinoma | 3/23 13% | 22/769 3% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Other Sarcomas | 6/69 9% | 11/699 2% |
| Hepatocellular Carcinoma | 3/46 7% | 43/2210 2% |
| Rhabdomyosarcoma | 1/33 3% | 3/171 2% |
| Kidney Carcinoma | 6/85 7% | 31/1862 2% |
| Thyroid Gland Carcinoma | 2/45 4% | 28/1592 2% |
| Non-Cancerous | 1/104 1% | 16/830 2% |
Mutation Distribution
Where LRRK2 is mutated · all tissues, split by cell line vs tissue
How many mutations in LRRK2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,650 mutations in LRRK2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|