Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,171 | 140 | 999 |
| Samples | 385 | 66 | 309 |
| Peptides | 243 | 39 | 209 |
Function
MAP2K7 · Mitogen-activated protein kinase kinase 7
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 215 amino-acid changes on canonical ENST00000397979 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MAP2K7 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MAP2K7 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Gastric Carcinoma | 3/74 4% | 63/1809 3% |
| Colorectal Carcinoma | 23/143 16% | 92/3239 3% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Endometrial Carcinoma | 3/42 7% | 6/612 1% |
| Germ Cell Tumour | 2/25 8% | 0/169 0% |
| Biliary Tract Carcinoma | 0/54 0% | 10/950 1% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 9/1390 1% |
| Ewings Sarcoma | 2/63 3% | 1/262 0% |
| Other Sarcomas | 2/69 3% | 5/699 1% |
| Melanoma | 4/210 2% | 15/1899 1% |
| Burkitts Lymphoma | 1/32 3% | 1/196 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Non-Cancerous | 0/104 0% | 6/830 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Other Solid Cancers | 1/94 1% | 9/1515 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 16/2550 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 5/810 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 9/1592 1% |
| Glioma | 0/52 0% | 11/2127 1% |
| Neuroendocrine Tumour | 0/154 0% | 3/577 1% |
| Pancreatic Carcinoma | 0/89 0% | 7/1611 0% |
| Bladder Carcinoma | 0/58 0% | 4/956 0% |
| Ovarian Carcinoma | 3/109 3% | 1/998 0% |
| Breast Carcinoma | 2/144 1% | 10/3264 0% |
| Prostate Carcinoma | 0/13 0% | 7/2105 0% |
| Hepatocellular Carcinoma | 2/46 4% | 5/2210 0% |
| Neuroblastoma | 0/87 0% | 4/1331 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
Mutation Distribution
Where MAP2K7 is mutated · all tissues, split by cell line vs tissue
How many mutations in MAP2K7 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,171 mutations in MAP2K7
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|