Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 653 | 132 | 505 |
| Samples | 588 | 126 | 453 |
| Peptides | 474 | 79 | 395 |
Function
MAP3K5 · Mitogen-activated protein kinase kinase kinase 5
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000359015 | Q99683 | 653 | 474 |
Gene Properties
Recurrent Mutations
All 474 amino-acid changes on canonical ENST00000359015 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MAP3K5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MAP3K5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 9/40 22% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 31/612 5% |
| Acute Myeloid Leukemia | 5/90 6% | 0/0 0% |
| Melanoma | 25/210 12% | 90/1899 5% |
| Bladder Carcinoma | 4/58 7% | 26/956 3% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Cervical Carcinoma | 2/35 6% | 9/422 2% |
| Plasma Cell Myeloma | 3/44 7% | 5/305 2% |
| Non-Small Cell Lung Carcinoma | 16/304 5% | 19/1390 1% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Colorectal Carcinoma | 8/143 6% | 59/3239 2% |
| Adrenocortical Carcinoma | 0/3 0% | 2/112 2% |
| Neuroendocrine Tumour | 7/154 5% | 5/577 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 12/810 1% |
| Germ Cell Tumour | 2/25 8% | 1/169 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Other Solid Cancers | 3/94 3% | 21/1515 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 11/752 1% |
| Gastric Carcinoma | 2/74 3% | 23/1809 1% |
| Ovarian Carcinoma | 5/109 5% | 7/998 1% |
| Other Sarcomas | 2/69 3% | 6/699 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 16/1592 1% |
| Head and Neck Carcinoma | 2/85 2% | 13/1574 1% |
| Glioma | 2/52 4% | 17/2127 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 18/2550 1% |
| Biliary Tract Carcinoma | 0/54 0% | 7/950 1% |
| Breast Carcinoma | 4/144 3% | 20/3264 1% |
| Non-Cancerous | 0/104 0% | 6/830 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| B-Cell Non-Hodgkins Lymphoma | 4/88 5% | 9/2534 0% |
Mutation Distribution
Where MAP3K5 is mutated · all tissues, split by cell line vs tissue
How many mutations in MAP3K5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 653 mutations in MAP3K5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|