Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 681 | 104 | 549 |
| Samples | 340 | 67 | 262 |
| Peptides | 280 | 52 | 229 |
Function
MAP4K2 · Mitogen-activated protein kinase kinase kinase kinase 2
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 270 amino-acid changes on canonical ENST00000294066 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MAP4K2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MAP4K2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Endometrial Carcinoma | 5/42 12% | 15/612 2% |
| Melanoma | 6/210 3% | 37/1899 2% |
| Gastric Carcinoma | 2/74 3% | 24/1809 1% |
| Squamous Cell Lung Carcinoma | 6/57 11% | 4/810 0% |
| Colorectal Carcinoma | 4/143 3% | 35/3239 1% |
| Cervical Carcinoma | 2/35 6% | 3/422 1% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 10/1390 1% |
| Other Solid Cancers | 0/94 0% | 15/1515 1% |
| Esophageal Carcinoma | 0/23 0% | 7/769 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 14/1592 1% |
| Hepatocellular Carcinoma | 0/46 0% | 19/2210 1% |
| Biliary Tract Carcinoma | 0/54 0% | 8/950 1% |
| Bladder Carcinoma | 1/58 2% | 7/956 1% |
| Other Sarcomas | 1/69 1% | 5/699 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Neuroendocrine Tumour | 5/154 3% | 0/577 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 13/2550 1% |
| Kidney Carcinoma | 2/85 2% | 7/1862 0% |
| Medulloblastoma | 0/0 0% | 2/450 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Head and Neck Carcinoma | 1/85 1% | 6/1574 0% |
| Glioma | 0/52 0% | 8/2127 0% |
| Pancreatic Carcinoma | 2/89 2% | 4/1611 0% |
| Breast Carcinoma | 2/144 1% | 10/3264 0% |
Mutation Distribution
Where MAP4K2 is mutated · all tissues, split by cell line vs tissue
How many mutations in MAP4K2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 681 mutations in MAP4K2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|