Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 510 | 38 | 467 |
| Samples | 181 | 21 | 158 |
| Peptides | 109 | 13 | 97 |
Function
MAPK1 · Mitogen-activated protein kinase 1
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 105 amino-acid changes on canonical ENST00000215832 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MAPK1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MAPK1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 13/422 3% |
| Endometrial Carcinoma | 1/42 2% | 7/612 1% |
| Head and Neck Carcinoma | 1/85 1% | 18/1574 1% |
| Bladder Carcinoma | 4/58 7% | 6/956 1% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Other Sarcomas | 0/69 0% | 5/699 1% |
| Melanoma | 1/210 0% | 11/1899 1% |
| Other Solid Cancers | 0/94 0% | 9/1515 1% |
| Colorectal Carcinoma | 6/143 4% | 12/3239 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 4/810 0% |
| Hepatocellular Carcinoma | 0/46 0% | 10/2210 0% |
| Gastric Carcinoma | 0/74 0% | 7/1809 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 9/2550 0% |
| Pancreatic Carcinoma | 0/89 0% | 5/1611 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 7/2534 0% |
| Breast Carcinoma | 4/144 3% | 5/3264 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 4/1390 0% |
| Glioma | 0/52 0% | 5/2127 0% |
| B-Lymphoblastic Leukemia | 0/55 0% | 4/2640 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Prostate Carcinoma | 0/13 0% | 3/2105 0% |
| Other Blood Cancers | 1/61 2% | 3/2725 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 2/1592 0% |
| Biliary Tract Carcinoma | 0/54 0% | 1/950 0% |
| Kidney Carcinoma | 0/85 0% | 2/1862 0% |
| Neuroblastoma | 0/87 0% | 1/1331 0% |
Mutation Distribution
Where MAPK1 is mutated · all tissues, split by cell line vs tissue
How many mutations in MAPK1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 510 mutations in MAPK1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|