Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 717 | 114 | 587 |
| Samples | 405 | 81 | 315 |
| Peptides | 300 | 52 | 253 |
Function
MARK4 · Microtubule affinity regulating kinase 4
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 279 amino-acid changes on canonical ENST00000262891 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MARK4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MARK4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 8/42 19% | 11/612 2% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Melanoma | 6/210 3% | 40/1899 2% |
| Colorectal Carcinoma | 10/143 7% | 63/3239 2% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Gastric Carcinoma | 1/74 1% | 26/1809 1% |
| Mesothelioma | 2/62 3% | 1/165 1% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 10/1390 1% |
| Other Sarcomas | 3/69 4% | 6/699 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 9/810 1% |
| Other Solid Cancers | 0/94 0% | 17/1515 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Bladder Carcinoma | 0/58 0% | 10/956 1% |
| Hepatocellular Carcinoma | 2/46 4% | 20/2210 1% |
| Neuroendocrine Tumour | 4/154 3% | 3/577 1% |
| Osteosarcoma | 1/45 2% | 1/166 1% |
| Head and Neck Carcinoma | 4/85 5% | 11/1574 1% |
| Plasma Cell Myeloma | 3/44 7% | 0/305 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Esophageal Carcinoma | 2/23 9% | 3/769 0% |
| Ovarian Carcinoma | 3/109 3% | 4/998 0% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Prostate Carcinoma | 2/13 15% | 11/2105 1% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Kidney Carcinoma | 5/85 6% | 5/1862 0% |
| Glioma | 0/52 0% | 11/2127 1% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
Mutation Distribution
Where MARK4 is mutated · all tissues, split by cell line vs tissue
How many mutations in MARK4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 717 mutations in MARK4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|