Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,642 | 146 | 1,470 |
| Samples | 230 | 41 | 186 |
| Peptides | 276 | 32 | 247 |
Function
MBP · Myelin basic protein
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
16 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000355994 | P02686 | 192 | 133 |
| ENST00000580402 | P02686 | 169 | 127 |
| ENST00000579129 | J3QQK6* | 137 | 107 |
| ENST00000397869 | H7BYR8* | 127 | 93 |
| ENST00000382582 | P02686-3 | 109 | 80 |
| ENST00000359645 | P02686-4 | 105 | 76 |
| ENST00000397875 | A8MZH3* | 104 | 74 |
| ENST00000397866 | P02686-5 | 101 | 73 |
| ENST00000397860 | P02686-2 | 100 | 82 |
| ENST00000397863 | P02686-2 | 100 | 82 |
| ENST00000397865 | P02686-6 | 97 | 69 |
| ENST00000526111 | E9PJ72* | 93 | 65 |
| ENST00000578193 | J3QL64* | 93 | 68 |
| ENST00000527041 | E9PKX9* | 44 | 37 |
| ENST00000354542 | F8WEU6* | 39 | 32 |
| ENST00000528160 | E9PQE7* | 32 | 26 |
Gene Properties
Recurrent Mutations
All 133 amino-acid changes on canonical ENST00000355994 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MBP · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MBP – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Endometrial Carcinoma | 3/42 7% | 16/612 3% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Colorectal Carcinoma | 12/143 8% | 28/3239 1% |
| Gastric Carcinoma | 0/74 0% | 19/1809 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 8/810 1% |
| Other Solid Cancers | 0/94 0% | 14/1515 1% |
| Melanoma | 5/210 2% | 12/1899 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Head and Neck Carcinoma | 2/85 2% | 8/1574 1% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Prostate Carcinoma | 0/13 0% | 10/2105 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Hepatocellular Carcinoma | 0/46 0% | 10/2210 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Wilms Tumour | 0/5 0% | 2/474 0% |
| Glioma | 0/52 0% | 9/2127 0% |
| Meningioma | 1/3 33% | 0/252 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 4/1390 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Kidney Carcinoma | 1/85 1% | 4/1862 0% |
| Breast Carcinoma | 0/144 0% | 8/3264 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Neuroblastoma | 2/87 2% | 1/1331 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| B-Lymphoblastic Leukemia | 3/55 5% | 2/2640 0% |
| Ovarian Carcinoma | 0/109 0% | 2/998 0% |
Mutation Distribution
Where MBP is mutated · all tissues, split by cell line vs tissue
How many mutations in MBP were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,642 mutations in MBP
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|