Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,646 | 288 | 2,324 |
| Samples | 535 | 91 | 433 |
| Peptides | 482 | 73 | 403 |
Function
MED23 · Mediator complex subunit 23
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 440 amino-acid changes on canonical ENST00000368068 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MED23 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MED23 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Endometrial Carcinoma | 5/42 12% | 37/612 6% |
| Melanoma | 9/210 4% | 60/1899 3% |
| Small Cell Lung Carcinoma | 2/9 22% | 19/752 3% |
| Unknown | 0/10 0% | 1/29 3% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 19/810 2% |
| Colorectal Carcinoma | 20/143 14% | 54/3239 2% |
| Gastric Carcinoma | 3/74 4% | 38/1809 2% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 21/1390 2% |
| Bladder Carcinoma | 1/58 2% | 14/956 1% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Cervical Carcinoma | 2/35 6% | 4/422 1% |
| Other Solid Cancers | 0/94 0% | 21/1515 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Other Sarcomas | 3/69 4% | 5/699 1% |
| Neuroendocrine Tumour | 5/154 3% | 2/577 0% |
| Osteosarcoma | 1/45 2% | 1/166 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Breast Carcinoma | 2/144 1% | 27/3264 1% |
| Biliary Tract Carcinoma | 1/54 2% | 7/950 1% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 16/2550 1% |
| Non-Cancerous | 1/104 1% | 5/830 1% |
| Ovarian Carcinoma | 3/109 3% | 4/998 0% |
| Hepatocellular Carcinoma | 0/46 0% | 14/2210 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 9/1592 1% |
| Prostate Carcinoma | 2/13 15% | 10/2105 0% |
| Head and Neck Carcinoma | 2/85 2% | 7/1574 0% |
| Pancreatic Carcinoma | 1/89 1% | 8/1611 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
Mutation Distribution
Where MED23 is mutated · all tissues, split by cell line vs tissue
How many mutations in MED23 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,646 mutations in MED23
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|