Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 844 | 118 | 692 |
| Samples | 427 | 75 | 336 |
| Peptides | 304 | 59 | 247 |
Function
MMP17 · Matrix metallopeptidase 17
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 295 amino-acid changes on canonical ENST00000360564 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MMP17 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MMP17 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Endometrial Carcinoma | 4/42 10% | 18/612 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Neuroendocrine Tumour | 11/154 7% | 5/577 1% |
| Melanoma | 2/210 1% | 40/1899 2% |
| Other Solid Cancers | 8/94 9% | 22/1515 1% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Colorectal Carcinoma | 10/143 7% | 51/3239 2% |
| Gastric Carcinoma | 2/74 3% | 30/1809 2% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 18/1390 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 9/810 1% |
| Glioma | 4/52 8% | 20/2127 1% |
| Hepatocellular Carcinoma | 0/46 0% | 23/2210 1% |
| Thyroid Gland Carcinoma | 2/45 4% | 13/1592 1% |
| Cervical Carcinoma | 2/35 6% | 2/422 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Non-Cancerous | 0/104 0% | 7/830 1% |
| Biliary Tract Carcinoma | 2/54 4% | 5/950 1% |
| Bladder Carcinoma | 0/58 0% | 7/956 1% |
| Ovarian Carcinoma | 0/109 0% | 6/998 1% |
| Kidney Carcinoma | 2/85 2% | 8/1862 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 11/2550 0% |
| Pancreatic Carcinoma | 0/89 0% | 8/1611 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Other Sarcomas | 2/69 3% | 1/699 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 7/2534 0% |
| B-Lymphoblastic Leukemia | 3/55 5% | 5/2640 0% |
| Breast Carcinoma | 0/144 0% | 10/3264 0% |
Mutation Distribution
Where MMP17 is mutated · all tissues, split by cell line vs tissue
How many mutations in MMP17 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 844 mutations in MMP17
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|