Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 270 | 54 | 210 |
| Samples | 86 | 23 | 60 |
| Peptides | 87 | 20 | 66 |
Function
MRPL22 · Mitochondrial ribosomal protein L22
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 64 amino-acid changes on canonical ENST00000523037 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MRPL22 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MRPL22 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chordoma | 2/7 29% | 1/13 8% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Endometrial Carcinoma | 1/42 2% | 4/612 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Hodgkins Lymphoma | 1/16 6% | 0/122 0% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 6/1390 0% |
| Gastric Carcinoma | 0/74 0% | 7/1809 0% |
| Melanoma | 1/210 0% | 6/1899 0% |
| Bladder Carcinoma | 0/58 0% | 3/956 0% |
| Hepatocellular Carcinoma | 2/46 4% | 4/2210 0% |
| Colorectal Carcinoma | 2/143 1% | 7/3239 0% |
| Other Solid Cancers | 0/94 0% | 4/1515 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 2/810 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 3/1592 0% |
| Ovarian Carcinoma | 2/109 2% | 0/998 0% |
| B-Lymphoblastic Leukemia | 4/55 7% | 0/2640 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| Kidney Carcinoma | 0/85 0% | 2/1862 0% |
| Biliary Tract Carcinoma | 0/54 0% | 1/950 0% |
| Prostate Carcinoma | 2/13 15% | 0/2105 0% |
| Breast Carcinoma | 0/144 0% | 3/3264 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 1/2550 0% |
| Neuroblastoma | 1/87 1% | 0/1331 0% |
| Glioma | 0/52 0% | 1/2127 0% |
| Other Blood Cancers | 1/61 2% | 0/2725 0% |
Mutation Distribution
Where MRPL22 is mutated · all tissues, split by cell line vs tissue
How many mutations in MRPL22 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 270 mutations in MRPL22
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|