Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 106 | 48 | 58 |
| Samples | 104 | 48 | 56 |
| Peptides | 68 | 22 | 51 |
Function
MT-CO3 · Cytochrome c oxidase subunit III
Predicted to enable electron transfer activity and oxidoreduction-driven active transmembrane transporter activity. Involved in respiratory chain complex IV assembly. Part of respiratory chain complex IV. Implicated in MELAS syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000362079 | P00414 | 106 | 68 |
Gene Properties
Recurrent Mutations
All 68 amino-acid changes on canonical ENST00000362079 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MT-CO3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MT-CO3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Cell Non-Hodgkins Lymphoma | 3/26 12% | 0/0 0% |
| Acute Monocytic Leukemia | 1/1 100% | 0/25 0% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Endometrial Carcinoma | 1/42 2% | 7/612 1% |
| Biliary Tract Carcinoma | 3/54 6% | 4/950 0% |
| Kidney Carcinoma | 2/85 2% | 9/1862 0% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 5/1390 0% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Neuroendocrine Tumour | 3/154 2% | 0/577 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Colorectal Carcinoma | 3/143 2% | 10/3239 0% |
| Melanoma | 3/210 1% | 4/1899 0% |
| Other Solid Cancers | 2/94 2% | 3/1515 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Breast Carcinoma | 5/144 3% | 3/3264 0% |
| Cervical Carcinoma | 1/35 3% | 0/422 0% |
| Non-Cancerous | 1/104 1% | 1/830 0% |
| Pancreatic Carcinoma | 3/89 3% | 0/1611 0% |
| Small Cell Lung Carcinoma | 1/9 11% | 0/752 0% |
| Hepatocellular Carcinoma | 2/46 4% | 1/2210 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 0/810 0% |
| Gastric Carcinoma | 0/74 0% | 2/1809 0% |
| Bladder Carcinoma | 1/58 2% | 0/956 0% |
| Neuroblastoma | 1/87 1% | 0/1331 0% |
| Head and Neck Carcinoma | 1/85 1% | 0/1574 0% |
| Prostate Carcinoma | 0/13 0% | 1/2105 0% |
| Other Blood Cancers | 1/61 2% | 0/2725 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 0/2550 0% |
Mutation Distribution
Where MT-CO3 is mutated · all tissues, split by cell line vs tissue
How many mutations in MT-CO3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 106 mutations in MT-CO3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|