Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,841 | 477 | 3,307 |
| Samples | 1,372 | 239 | 1,110 |
| Peptides | 1,097 | 179 | 944 |
Function
MYO16 · Myosin XVI
This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 1008 amino-acid changes on canonical ENST00000356711 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MYO16 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MYO16 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 10/40 25% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 3/26 12% | 0/0 0% |
| Endometrial Carcinoma | 8/42 19% | 48/612 8% |
| Oral Cavity Carcinoma | 4/54 7% | 0/0 0% |
| Melanoma | 22/210 10% | 119/1899 6% |
| Non-Small Cell Lung Carcinoma | 38/304 12% | 64/1390 5% |
| Squamous Cell Lung Carcinoma | 5/57 9% | 47/810 6% |
| Colorectal Carcinoma | 19/143 13% | 158/3239 5% |
| Other Solid Cancers | 1/94 1% | 83/1515 5% |
| Gastric Carcinoma | 7/74 9% | 89/1809 5% |
| Bladder Carcinoma | 6/58 10% | 37/956 4% |
| Small Cell Lung Carcinoma | 1/9 11% | 29/752 4% |
| Other Sarcomas | 8/69 12% | 18/699 3% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 75/2550 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Hodgkins Lymphoma | 2/16 12% | 2/122 2% |
| Cervical Carcinoma | 4/35 11% | 9/422 2% |
| Ovarian Carcinoma | 11/109 10% | 19/998 2% |
| Neuroendocrine Tumour | 15/154 10% | 4/577 1% |
| Germ Cell Tumour | 3/25 12% | 2/169 1% |
| Unknown | 0/10 0% | 1/29 3% |
| Esophageal Carcinoma | 0/23 0% | 20/769 3% |
| Osteosarcoma | 4/45 9% | 1/166 1% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Head and Neck Carcinoma | 4/85 5% | 32/1574 2% |
| Non-Cancerous | 1/104 1% | 19/830 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Biliary Tract Carcinoma | 3/54 6% | 14/950 1% |
| Pancreatic Carcinoma | 5/89 6% | 22/1611 1% |
| Ewings Sarcoma | 2/63 3% | 3/262 1% |
Mutation Distribution
Where MYO16 is mutated · all tissues, split by cell line vs tissue
How many mutations in MYO16 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,841 mutations in MYO16
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|