Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 471 | 101 | 364 |
| Samples | 434 | 94 | 335 |
| Peptides | 350 | 63 | 291 |
Function
MYO1E · Myosin IE
This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000288235 | Q12965 | 471 | 350 |
Gene Properties
Recurrent Mutations
All 350 amino-acid changes on canonical ENST00000288235 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MYO1E · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MYO1E – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Chordoma | 2/7 29% | 0/13 0% |
| Endometrial Carcinoma | 7/42 17% | 24/612 4% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Plasma Cell Myeloma | 5/44 11% | 2/305 1% |
| Colorectal Carcinoma | 14/143 10% | 52/3239 2% |
| Cervical Carcinoma | 2/35 6% | 6/422 1% |
| Squamous Cell Lung Carcinoma | 5/57 9% | 10/810 1% |
| Bladder Carcinoma | 2/58 3% | 15/956 2% |
| Melanoma | 1/210 0% | 33/1899 2% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 16/1390 1% |
| Head and Neck Carcinoma | 6/85 7% | 12/1574 1% |
| Gastric Carcinoma | 2/74 3% | 18/1809 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Other Solid Cancers | 0/94 0% | 16/1515 1% |
| Hepatocellular Carcinoma | 0/46 0% | 22/2210 1% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Ovarian Carcinoma | 4/109 4% | 5/998 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Glioma | 0/52 0% | 15/2127 1% |
| Prostate Carcinoma | 0/13 0% | 12/2105 1% |
| B-Cell Non-Hodgkins Lymphoma | 5/88 6% | 10/2534 0% |
| Breast Carcinoma | 4/144 3% | 15/3264 0% |
| Neuroendocrine Tumour | 2/154 1% | 2/577 0% |
| Other Sarcomas | 1/69 1% | 3/699 0% |
| Pancreatic Carcinoma | 0/89 0% | 8/1611 0% |
Mutation Distribution
Where MYO1E is mutated · all tissues, split by cell line vs tissue
How many mutations in MYO1E were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 471 mutations in MYO1E
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|