Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,874 | 292 | 1,566 |
| Samples | 1,036 | 191 | 834 |
| Peptides | 799 | 162 | 676 |
Function
MYOM2 · Myomesin 2
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 794 amino-acid changes on canonical ENST00000262113 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MYOM2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MYOM2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Glioblastoma | 8/98 8% | 0/0 0% |
| Endometrial Carcinoma | 9/42 21% | 44/612 7% |
| Melanoma | 19/210 9% | 149/1899 8% |
| Acute Myeloid Leukemia | 5/90 6% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 20/304 7% | 65/1390 5% |
| Other Solid Cancers | 2/94 2% | 69/1515 5% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Hodgkins Lymphoma | 2/16 12% | 3/122 2% |
| Colorectal Carcinoma | 24/143 17% | 97/3239 3% |
| Gastric Carcinoma | 2/74 3% | 60/1809 3% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 23/810 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Burkitts Lymphoma | 5/32 16% | 1/196 1% |
| Bladder Carcinoma | 4/58 7% | 20/956 2% |
| Cervical Carcinoma | 1/35 3% | 9/422 2% |
| Neuroendocrine Tumour | 10/154 6% | 6/577 1% |
| Ewings Sarcoma | 3/63 5% | 4/262 2% |
| Small Cell Lung Carcinoma | 1/9 11% | 15/752 2% |
| Biliary Tract Carcinoma | 7/54 13% | 12/950 1% |
| Esophageal Carcinoma | 1/23 4% | 14/769 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Ovarian Carcinoma | 8/109 7% | 12/998 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 29/1592 2% |
| Osteosarcoma | 2/45 4% | 1/166 1% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 33/2550 1% |
| Head and Neck Carcinoma | 2/85 2% | 18/1574 1% |
| Other Sarcomas | 3/69 4% | 6/699 1% |
| Hepatocellular Carcinoma | 1/46 2% | 25/2210 1% |
Mutation Distribution
Where MYOM2 is mutated · all tissues, split by cell line vs tissue
How many mutations in MYOM2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,874 mutations in MYOM2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|