Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,615 | 228 | 1,377 |
| Samples | 572 | 108 | 460 |
| Peptides | 483 | 69 | 434 |
Function
NAALAD2 · N-acetylated alpha-linked acidic dipeptidase 2
This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 417 amino-acid changes on canonical ENST00000534061 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NAALAD2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NAALAD2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Oral Cavity Carcinoma | 4/54 7% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 27/612 4% |
| Chordoma | 0/7 0% | 1/13 8% |
| Melanoma | 1/210 0% | 79/1899 4% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 28/810 3% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 23/304 8% | 29/1390 2% |
| Colorectal Carcinoma | 17/143 12% | 59/3239 2% |
| Other Solid Cancers | 3/94 3% | 33/1515 2% |
| Small Cell Lung Carcinoma | 1/9 11% | 16/752 2% |
| Hodgkins Lymphoma | 2/16 12% | 1/122 1% |
| Gastric Carcinoma | 2/74 3% | 28/1809 2% |
| Esophageal Carcinoma | 0/23 0% | 10/769 1% |
| Neuroendocrine Tumour | 4/154 3% | 3/577 1% |
| Bladder Carcinoma | 4/58 7% | 5/956 1% |
| Cervical Carcinoma | 2/35 6% | 2/422 0% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Biliary Tract Carcinoma | 2/54 4% | 6/950 1% |
| Head and Neck Carcinoma | 0/85 0% | 13/1574 1% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 17/2550 1% |
| Hepatocellular Carcinoma | 0/46 0% | 17/2210 1% |
| Pancreatic Carcinoma | 3/89 3% | 8/1611 0% |
| Glioma | 0/52 0% | 13/2127 1% |
| Breast Carcinoma | 7/144 5% | 13/3264 0% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
| Kidney Carcinoma | 1/85 1% | 10/1862 1% |
| Ovarian Carcinoma | 2/109 2% | 4/998 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| B-Lymphoblastic Leukemia | 3/55 5% | 9/2640 0% |
Mutation Distribution
Where NAALAD2 is mutated · all tissues, split by cell line vs tissue
How many mutations in NAALAD2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,615 mutations in NAALAD2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|