Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,995 | 263 | 1,700 |
| Samples | 543 | 93 | 439 |
| Peptides | 455 | 71 | 378 |
Function
NEDD4 · NEDD4 E3 ubiquitin protein ligase
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 399 amino-acid changes on canonical ENST00000508342 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NEDD4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NEDD4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 8/42 19% | 33/612 5% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Melanoma | 7/210 3% | 50/1899 3% |
| Colorectal Carcinoma | 19/143 13% | 69/3239 2% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Gastric Carcinoma | 3/74 4% | 38/1809 2% |
| Hodgkins Lymphoma | 1/16 6% | 2/122 2% |
| Cervical Carcinoma | 1/35 3% | 8/422 2% |
| Rhabdomyosarcoma | 3/33 9% | 1/171 1% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 23/1390 2% |
| Other Solid Cancers | 2/94 2% | 21/1515 1% |
| Bladder Carcinoma | 3/58 5% | 10/956 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 9/810 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Head and Neck Carcinoma | 0/85 0% | 18/1574 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 22/2550 1% |
| Osteosarcoma | 1/45 2% | 1/166 1% |
| Ewings Sarcoma | 1/63 2% | 2/262 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Mesothelioma | 1/62 2% | 1/165 1% |
| Glioma | 0/52 0% | 18/2127 1% |
| Neuroendocrine Tumour | 5/154 3% | 1/577 0% |
| Ovarian Carcinoma | 3/109 3% | 6/998 1% |
| Hepatocellular Carcinoma | 1/46 2% | 17/2210 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 13/1592 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Esophageal Carcinoma | 2/23 9% | 4/769 1% |
| Non-Cancerous | 0/104 0% | 7/830 1% |
Mutation Distribution
Where NEDD4 is mutated · all tissues, split by cell line vs tissue
How many mutations in NEDD4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,995 mutations in NEDD4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|