Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,511 | 512 | 2,979 |
| Samples | 434 | 107 | 323 |
| Peptides | 393 | 80 | 322 |
Function
NOX4 · NADPH oxidase 4
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009].
Isoforms & Proteins
12 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000263317 | Q9NPH5 | 447 | 316 |
| ENST00000343727 | Q9NPH5-8 | 384 | 290 |
| ENST00000528341 | E9PPP2* | 384 | 289 |
| ENST00000424319 | Q9NPH5-8 | 383 | 289 |
| ENST00000527956 | Q9NPH5-8 | 383 | 289 |
| ENST00000534731 | Q9NPH5-6 | 368 | 277 |
| ENST00000532825 | Q9NPH5-9 | 363 | 272 |
| ENST00000527626 | E9PR43* | 279 | 206 |
| ENST00000525196 | E9PI95* | 209 | 167 |
| ENST00000375979 | Q9NPH5-4 | 158 | 117 |
| ENST00000531342 | Q9NPH5-3 | 138 | 100 |
| ENST00000393282 | Q9NPH5-7 | 15 | 14 |
Gene Properties
Recurrent Mutations
All 316 amino-acid changes on canonical ENST00000263317 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NOX4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NOX4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Unknown | 0/10 0% | 2/29 7% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Endometrial Carcinoma | 5/42 12% | 20/612 3% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 17/810 2% |
| Chondrosarcoma | 1/14 7% | 1/75 1% |
| Gastric Carcinoma | 7/74 9% | 31/1809 2% |
| Melanoma | 5/210 2% | 37/1899 2% |
| Colorectal Carcinoma | 10/143 7% | 51/3239 2% |
| Other Solid Cancers | 2/94 2% | 26/1515 2% |
| Non-Small Cell Lung Carcinoma | 12/304 4% | 16/1390 1% |
| Neuroendocrine Tumour | 8/154 5% | 4/577 1% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Plasma Cell Myeloma | 2/44 5% | 2/305 1% |
| Esophageal Carcinoma | 0/23 0% | 9/769 1% |
| Bladder Carcinoma | 2/58 3% | 9/956 1% |
| Germ Cell Tumour | 2/25 8% | 0/169 0% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Ovarian Carcinoma | 5/109 5% | 3/998 0% |
| B-Cell Non-Hodgkins Lymphoma | 8/88 9% | 10/2534 0% |
| Non-Cancerous | 0/104 0% | 6/830 1% |
| Glioma | 1/52 2% | 10/2127 0% |
| Hepatocellular Carcinoma | 0/46 0% | 11/2210 0% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Kidney Carcinoma | 4/85 5% | 5/1862 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 5/1592 0% |
Mutation Distribution
Where NOX4 is mutated · all tissues, split by cell line vs tissue
How many mutations in NOX4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 52 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,511 mutations in NOX4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|