Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,726 | 401 | 2,286 |
| Samples | 682 | 146 | 525 |
| Peptides | 670 | 118 | 556 |
Function
NRCAM · Neuronal cell adhesion molecule
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 581 amino-acid changes on canonical ENST00000379028 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NRCAM · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NRCAM – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 7/133 5% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 29/304 10% | 49/1390 4% |
| Endometrial Carcinoma | 5/42 12% | 24/612 4% |
| Melanoma | 15/210 7% | 57/1899 3% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 23/752 3% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 20/810 2% |
| Colorectal Carcinoma | 17/143 12% | 68/3239 2% |
| Bladder Carcinoma | 2/58 3% | 23/956 2% |
| Other Solid Cancers | 3/94 3% | 34/1515 2% |
| Neuroendocrine Tumour | 13/154 8% | 2/577 0% |
| Cervical Carcinoma | 2/35 6% | 7/422 2% |
| Gastric Carcinoma | 4/74 5% | 33/1809 2% |
| Burkitts Lymphoma | 4/32 12% | 0/196 0% |
| Head and Neck Carcinoma | 6/85 7% | 22/1574 1% |
| Plasma Cell Myeloma | 2/44 5% | 2/305 1% |
| Hepatocellular Carcinoma | 1/46 2% | 24/2210 1% |
| Biliary Tract Carcinoma | 2/54 4% | 9/950 1% |
| Germ Cell Tumour | 1/25 4% | 1/169 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Glioma | 2/52 4% | 15/2127 1% |
| Other Sarcomas | 0/69 0% | 6/699 1% |
| Kidney Carcinoma | 4/85 5% | 11/1862 1% |
| Breast Carcinoma | 5/144 3% | 20/3264 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Pancreatic Carcinoma | 3/89 3% | 8/1611 0% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
Mutation Distribution
Where NRCAM is mutated · all tissues, split by cell line vs tissue
How many mutations in NRCAM were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,726 mutations in NRCAM
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|