Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,904 | 391 | 3,410 |
| Samples | 883 | 107 | 756 |
| Peptides | 779 | 99 | 691 |
Function
NRG1 · Neuregulin 1
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016].
Isoforms & Proteins
9 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000405005 | Q02297 | 686 | 399 |
| ENST00000287842 | Q02297-6 | 657 | 407 |
| ENST00000519301 | Q02297-11 | 632 | 384 |
| ENST00000356819 | Q02297-7 | 628 | 383 |
| ENST00000521670 | Q02297-3 | 387 | 249 |
| ENST00000523079 | Q02297-12 | 378 | 233 |
| ENST00000520407 | Q02297-9 | 282 | 183 |
| ENST00000520502 | Q02297-10 | 253 | 173 |
| ENST00000518206 | H0YCP0* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 399 amino-acid changes on canonical ENST00000405005 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NRG1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NRG1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Endometrial Carcinoma | 5/42 12% | 39/612 6% |
| Melanoma | 13/210 6% | 108/1899 6% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 7/133 5% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Colorectal Carcinoma | 20/143 14% | 138/3239 4% |
| Esophageal Carcinoma | 0/23 0% | 37/769 5% |
| Gastric Carcinoma | 2/74 3% | 77/1809 4% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Chondrosarcoma | 3/14 21% | 0/75 0% |
| Other Solid Cancers | 1/94 1% | 46/1515 3% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 32/1390 2% |
| Bladder Carcinoma | 4/58 7% | 19/956 2% |
| Burkitts Lymphoma | 5/32 16% | 0/196 0% |
| Non-Cancerous | 2/104 2% | 17/830 2% |
| Neuroendocrine Tumour | 3/154 2% | 10/577 2% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Plasma Cell Myeloma | 0/44 0% | 5/305 2% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 9/810 1% |
| Biliary Tract Carcinoma | 0/54 0% | 13/950 1% |
| Ovarian Carcinoma | 7/109 6% | 7/998 1% |
| Prostate Carcinoma | 3/13 23% | 21/2105 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Cervical Carcinoma | 1/35 3% | 4/422 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 8/752 1% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 24/2534 1% |
| Hepatocellular Carcinoma | 0/46 0% | 23/2210 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 24/2550 1% |
| Glioma | 0/52 0% | 21/2127 1% |
Mutation Distribution
Where NRG1 is mutated · all tissues, split by cell line vs tissue
How many mutations in NRG1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,904 mutations in NRG1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|