Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,970 | 224 | 1,723 |
| Samples | 388 | 85 | 298 |
| Peptides | 339 | 71 | 277 |
Function
NRG2 · Neuregulin 2
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 279 amino-acid changes on canonical ENST00000361474 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NRG2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NRG2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Rhabdomyosarcoma | 0/33 0% | 5/171 3% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 7/612 1% |
| Germ Cell Tumour | 1/25 4% | 3/169 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Adrenocortical Carcinoma | 1/3 33% | 1/112 1% |
| Colorectal Carcinoma | 10/143 7% | 45/3239 1% |
| Gastric Carcinoma | 3/74 4% | 27/1809 1% |
| Melanoma | 2/210 1% | 30/1899 2% |
| Other Solid Cancers | 1/94 1% | 23/1515 2% |
| Thyroid Gland Carcinoma | 2/45 4% | 22/1592 1% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 14/1390 1% |
| Non-Cancerous | 3/104 3% | 8/830 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 9/810 1% |
| Ovarian Carcinoma | 7/109 6% | 4/998 0% |
| Neuroendocrine Tumour | 4/154 3% | 3/577 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Hepatocellular Carcinoma | 2/46 4% | 16/2210 1% |
| Head and Neck Carcinoma | 3/85 4% | 10/1574 1% |
| Other Sarcomas | 1/69 1% | 4/699 1% |
| Ewings Sarcoma | 2/63 3% | 0/262 0% |
| Pancreatic Carcinoma | 1/89 1% | 8/1611 0% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Kidney Carcinoma | 2/85 2% | 7/1862 0% |
| Glioma | 1/52 2% | 9/2127 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Bladder Carcinoma | 2/58 3% | 2/956 0% |
Mutation Distribution
Where NRG2 is mutated · all tissues, split by cell line vs tissue
How many mutations in NRG2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,970 mutations in NRG2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|