Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,427 | 433 | 2,928 |
| Samples | 1,011 | 187 | 813 |
| Peptides | 832 | 151 | 703 |
Function
NRXN2 · Neurexin 2
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000265459 | Q9P2S2 | 1,123 | 746 |
| ENST00000409571 | G5E9G7* | 993 | 694 |
| ENST00000377559 | Q9P2S2-2 | 950 | 663 |
| ENST00000301894 | P58401 | 357 | 259 |
| ENST00000704782 | A0A994J5C3* | 4 | 4 |
Gene Properties
Recurrent Mutations
All 746 amino-acid changes on canonical ENST00000265459 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NRXN2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NRXN2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Endometrial Carcinoma | 9/42 21% | 35/612 6% |
| Melanoma | 24/210 11% | 94/1899 5% |
| Gastric Carcinoma | 10/74 14% | 72/1809 4% |
| Colorectal Carcinoma | 22/143 15% | 121/3239 4% |
| Other Solid Cancers | 5/94 5% | 62/1515 4% |
| Non-Small Cell Lung Carcinoma | 19/304 6% | 43/1390 3% |
| Hodgkins Lymphoma | 2/16 12% | 3/122 2% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 26/810 3% |
| Cervical Carcinoma | 4/35 11% | 9/422 2% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 56/2550 2% |
| Other Sarcomas | 4/69 6% | 11/699 2% |
| Thyroid Gland Carcinoma | 0/45 0% | 30/1592 2% |
| Ovarian Carcinoma | 8/109 7% | 12/998 1% |
| Burkitts Lymphoma | 4/32 12% | 0/196 0% |
| Head and Neck Carcinoma | 4/85 5% | 24/1574 2% |
| Bladder Carcinoma | 1/58 2% | 16/956 2% |
| Esophageal Carcinoma | 1/23 4% | 12/769 2% |
| Non-Cancerous | 1/104 1% | 14/830 2% |
| Biliary Tract Carcinoma | 3/54 6% | 13/950 1% |
| Hepatocellular Carcinoma | 0/46 0% | 34/2210 2% |
| Neuroendocrine Tumour | 8/154 5% | 3/577 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Plasma Cell Myeloma | 1/44 2% | 4/305 1% |
| Breast Carcinoma | 19/144 13% | 26/3264 1% |
| Pancreatic Carcinoma | 2/89 2% | 19/1611 1% |
| Small Cell Lung Carcinoma | 1/9 11% | 8/752 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
Mutation Distribution
Where NRXN2 is mutated · all tissues, split by cell line vs tissue
How many mutations in NRXN2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,427 mutations in NRXN2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|