Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 480 | 58 | 415 |
| Samples | 449 | 53 | 389 |
| Peptides | 315 | 48 | 279 |
Function
NT5C1B-RDH14 · NT5C1B-RDH14 readthrough
This locus represents naturally occurring read-through transcription between the neighboring NT5C1B (5'-nucleotidase, cytosolic IB) and RDH14 (retinol dehydrogenase 14) genes on chromosome 2. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Nov 2010].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000532967 | Q96P26-4 | 480 | 315 |
Gene Properties
Recurrent Mutations
All 316 amino-acid changes on canonical ENST00000532967 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NT5C1B-RDH14 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NT5C1B-RDH14 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Melanoma | 3/210 1% | 86/1899 5% |
| Endometrial Carcinoma | 1/42 2% | 23/612 4% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 12/304 4% | 23/1390 2% |
| Colorectal Carcinoma | 9/143 6% | 56/3239 2% |
| Gastric Carcinoma | 1/74 1% | 31/1809 2% |
| Other Solid Cancers | 3/94 3% | 19/1515 1% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 6/810 1% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Non-Cancerous | 0/104 0% | 8/830 1% |
| Neuroendocrine Tumour | 3/154 2% | 3/577 1% |
| Esophageal Carcinoma | 0/23 0% | 6/769 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Head and Neck Carcinoma | 0/85 0% | 12/1574 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Other Sarcomas | 0/69 0% | 5/699 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 9/1592 1% |
| Ovarian Carcinoma | 1/109 1% | 5/998 0% |
| Kidney Carcinoma | 1/85 1% | 9/1862 0% |
| Glioma | 0/52 0% | 11/2127 1% |
| B-Lymphoblastic Leukemia | 2/55 4% | 11/2640 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Medulloblastoma | 0/0 0% | 2/450 0% |
| Hepatocellular Carcinoma | 2/46 4% | 8/2210 0% |
| Pancreatic Carcinoma | 1/89 1% | 6/1611 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 9/2550 0% |
Mutation Distribution
Where NT5C1B-RDH14 is mutated · all tissues, split by cell line vs tissue
How many mutations in NT5C1B-RDH14 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 480 mutations in NT5C1B-RDH14
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|