Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 272 | 59 | 211 |
| Samples | 260 | 54 | 204 |
| Peptides | 172 | 42 | 141 |
Function
NTSR2 · Neurotensin receptor 2
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000306928 | O95665 | 272 | 172 |
Gene Properties
Recurrent Mutations
All 172 amino-acid changes on canonical ENST00000306928 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NTSR2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NTSR2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Colorectal Carcinoma | 14/143 10% | 55/3239 2% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 7/1390 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 8/810 1% |
| Gastric Carcinoma | 3/74 4% | 14/1809 1% |
| Melanoma | 1/210 0% | 18/1899 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 13/1592 1% |
| Other Sarcomas | 2/69 3% | 4/699 1% |
| Endometrial Carcinoma | 1/42 2% | 4/612 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Head and Neck Carcinoma | 2/85 2% | 9/1574 1% |
| Other Solid Cancers | 0/94 0% | 9/1515 1% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 12/2550 0% |
| Hepatocellular Carcinoma | 1/46 2% | 9/2210 0% |
| Neuroendocrine Tumour | 3/154 2% | 0/577 0% |
| Ovarian Carcinoma | 1/109 1% | 2/998 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| B-Lymphoblastic Leukemia | 5/55 9% | 2/2640 0% |
| Pancreatic Carcinoma | 0/89 0% | 4/1611 0% |
| Glioma | 0/52 0% | 5/2127 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Breast Carcinoma | 1/144 1% | 6/3264 0% |
| Biliary Tract Carcinoma | 0/54 0% | 2/950 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 4/2534 0% |
| Prostate Carcinoma | 1/13 8% | 2/2105 0% |
| Other Blood Cancers | 0/61 0% | 3/2725 0% |
| Kidney Carcinoma | 2/85 2% | 0/1862 0% |
Mutation Distribution
Where NTSR2 is mutated · all tissues, split by cell line vs tissue
How many mutations in NTSR2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 40 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 272 mutations in NTSR2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|