Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,692 | 284 | 1,374 |
| Samples | 578 | 139 | 427 |
| Peptides | 467 | 91 | 369 |
Function
NUP155 · Nucleoporin 155
Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 461 amino-acid changes on canonical ENST00000231498 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in NUP155 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in NUP155 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Cell Non-Hodgkins Lymphoma | 3/26 12% | 0/0 0% |
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Oral Cavity Carcinoma | 4/54 7% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 24/612 4% |
| Melanoma | 12/210 6% | 65/1899 3% |
| Cervical Carcinoma | 3/35 9% | 11/422 3% |
| Hodgkins Lymphoma | 2/16 12% | 2/122 2% |
| Plasma Cell Myeloma | 1/44 2% | 9/305 3% |
| Bladder Carcinoma | 6/58 10% | 23/956 2% |
| Colorectal Carcinoma | 18/143 13% | 64/3239 2% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 16/810 2% |
| Other Solid Cancers | 3/94 3% | 29/1515 2% |
| Non-Small Cell Lung Carcinoma | 12/304 4% | 21/1390 2% |
| Neuroendocrine Tumour | 9/154 6% | 3/577 1% |
| Germ Cell Tumour | 2/25 8% | 1/169 1% |
| Ewings Sarcoma | 2/63 3% | 3/262 1% |
| Gastric Carcinoma | 4/74 5% | 25/1809 1% |
| Rhabdomyosarcoma | 3/33 9% | 0/171 0% |
| Esophageal Squamous Cell Carcinoma | 5/51 10% | 25/2550 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Breast Carcinoma | 12/144 8% | 20/3264 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Other Sarcomas | 2/69 3% | 5/699 1% |
| Hepatocellular Carcinoma | 2/46 4% | 18/2210 1% |
| Esophageal Carcinoma | 0/23 0% | 7/769 1% |
| Burkitts Lymphoma | 1/32 3% | 1/196 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Ovarian Carcinoma | 1/109 1% | 7/998 1% |
| Head and Neck Carcinoma | 1/85 1% | 9/1574 1% |
| Glioma | 2/52 4% | 10/2127 0% |
Mutation Distribution
Where NUP155 is mutated · all tissues, split by cell line vs tissue
How many mutations in NUP155 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,692 mutations in NUP155
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|