Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 84 | 75 | 0 |
| Samples | 77 | 70 | 0 |
| Peptides | 79 | 70 | 0 |
Function
ODAD2 · Outer dynein arm docking complex subunit 2
The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 79 amino-acid changes on canonical ENST00000305242 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ODAD2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ODAD2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 1/612 0% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Melanoma | 11/210 5% | 2/1899 0% |
| Neuroendocrine Tumour | 4/154 3% | 0/577 0% |
| Meningioma | 1/3 33% | 0/252 0% |
| Bladder Carcinoma | 3/58 5% | 1/956 0% |
| Other Sarcomas | 3/69 4% | 0/699 0% |
| Colorectal Carcinoma | 11/143 8% | 0/3239 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Gastric Carcinoma | 5/74 7% | 0/1809 0% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 1/1390 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 0/810 0% |
| Cervical Carcinoma | 1/35 3% | 0/422 0% |
| Neuroblastoma | 2/87 2% | 0/1331 0% |
| Small Cell Lung Carcinoma | 1/9 11% | 0/752 0% |
| Non-Cancerous | 1/104 1% | 0/830 0% |
| Breast Carcinoma | 3/144 2% | 0/3264 0% |
| Ovarian Carcinoma | 1/109 1% | 0/998 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 0/2534 0% |
| Head and Neck Carcinoma | 0/85 0% | 1/1574 0% |
| Other Solid Cancers | 1/94 1% | 0/1515 0% |
| Prostate Carcinoma | 0/13 0% | 1/2105 0% |
| Glioma | 1/52 2% | 0/2127 0% |
| Hepatocellular Carcinoma | 1/46 2% | 0/2210 0% |
Mutation Distribution
Where ODAD2 is mutated · all tissues, split by cell line vs tissue
How many mutations in ODAD2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 84 mutations in ODAD2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|