Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,448 | 120 | 1,311 |
| Samples | 471 | 56 | 410 |
| Peptides | 321 | 48 | 282 |
Function
OPRK1 · Opioid receptor kappa 1
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 291 amino-acid changes on canonical ENST00000265572 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in OPRK1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in OPRK1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Melanoma | 6/210 3% | 65/1899 3% |
| Endometrial Carcinoma | 5/42 12% | 15/612 2% |
| Gastric Carcinoma | 0/74 0% | 49/1809 3% |
| Unknown | 0/10 0% | 1/29 3% |
| Other Solid Cancers | 0/94 0% | 41/1515 3% |
| Colorectal Carcinoma | 6/143 4% | 63/3239 2% |
| Mesothelioma | 4/62 6% | 0/165 0% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 21/1390 2% |
| Esophageal Carcinoma | 2/23 9% | 7/769 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 8/752 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 27/2550 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 7/810 1% |
| Bladder Carcinoma | 0/58 0% | 8/956 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Hepatocellular Carcinoma | 0/46 0% | 16/2210 1% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Kidney Carcinoma | 0/85 0% | 12/1862 1% |
| Neuroendocrine Tumour | 2/154 1% | 2/577 0% |
| Head and Neck Carcinoma | 0/85 0% | 9/1574 1% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 13/2534 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Glioma | 0/52 0% | 10/2127 0% |
| Cervical Carcinoma | 2/35 6% | 0/422 0% |
| Non-Cancerous | 0/104 0% | 4/830 0% |
Mutation Distribution
Where OPRK1 is mutated · all tissues, split by cell line vs tissue
How many mutations in OPRK1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 38 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,448 mutations in OPRK1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|