Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 762 | 101 | 648 |
| Samples | 263 | 46 | 212 |
| Peptides | 187 | 32 | 160 |
Function
OPRL1 · Opioid related nociceptin receptor 1
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000336866 | P41146 | 270 | 185 |
| ENST00000355631 | P41146 | 246 | 179 |
| ENST00000349451 | P41146 | 245 | 178 |
| ENST00000615600 | A0A0G2JQE4* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 185 amino-acid changes on canonical ENST00000336866 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in OPRL1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in OPRL1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Endometrial Carcinoma | 2/42 5% | 10/612 2% |
| Colorectal Carcinoma | 16/143 11% | 34/3239 1% |
| Melanoma | 0/210 0% | 31/1899 2% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 12/810 1% |
| Plasma Cell Myeloma | 0/44 0% | 4/305 1% |
| Gastric Carcinoma | 2/74 3% | 19/1809 1% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 16/1390 1% |
| Cervical Carcinoma | 2/35 6% | 3/422 1% |
| Other Solid Cancers | 0/94 0% | 14/1515 1% |
| Head and Neck Carcinoma | 4/85 5% | 7/1574 0% |
| Non-Cancerous | 0/104 0% | 6/830 1% |
| Ewings Sarcoma | 2/63 3% | 0/262 0% |
| Neuroendocrine Tumour | 3/154 2% | 1/577 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Glioma | 0/52 0% | 11/2127 1% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Pancreatic Carcinoma | 1/89 1% | 5/1611 0% |
| Breast Carcinoma | 2/144 1% | 8/3264 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 5/2550 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Bladder Carcinoma | 0/58 0% | 2/956 0% |
| Prostate Carcinoma | 0/13 0% | 4/2105 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 4/2534 0% |
| Ovarian Carcinoma | 0/109 0% | 2/998 0% |
| Neuroblastoma | 0/87 0% | 2/1331 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
Mutation Distribution
Where OPRL1 is mutated · all tissues, split by cell line vs tissue
How many mutations in OPRL1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 762 mutations in OPRL1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|