Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 857 | 124 | 723 |
| Samples | 206 | 43 | 158 |
| Peptides | 166 | 32 | 133 |
Function
ORC4 · Origin recognition complex subunit 4
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 158 amino-acid changes on canonical ENST00000392857 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ORC4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ORC4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Endometrial Carcinoma | 2/42 5% | 18/612 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Colorectal Carcinoma | 7/143 5% | 27/3239 1% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 10/1390 1% |
| Melanoma | 0/210 0% | 18/1899 1% |
| Bladder Carcinoma | 0/58 0% | 8/956 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 12/1592 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Other Solid Cancers | 0/94 0% | 8/1515 1% |
| Hepatocellular Carcinoma | 2/46 4% | 9/2210 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 2/810 0% |
| Gastric Carcinoma | 2/74 3% | 6/1809 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Kidney Carcinoma | 2/85 2% | 4/1862 0% |
| Biliary Tract Carcinoma | 0/54 0% | 3/950 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Head and Neck Carcinoma | 1/85 1% | 3/1574 0% |
| Neuroblastoma | 3/87 3% | 0/1331 0% |
| Pancreatic Carcinoma | 2/89 2% | 1/1611 0% |
| Breast Carcinoma | 1/144 1% | 5/3264 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 2/2534 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 2/2550 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Non-Cancerous | 0/104 0% | 1/830 0% |
Mutation Distribution
Where ORC4 is mutated · all tissues, split by cell line vs tissue
How many mutations in ORC4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 857 mutations in ORC4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|