Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 374 | 73 | 298 |
| Samples | 351 | 69 | 279 |
| Peptides | 288 | 51 | 239 |
Function
PADI1 · Peptidyl arginine deiminase 1
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000375471 | Q9ULC6 | 374 | 288 |
Gene Properties
Recurrent Mutations
All 288 amino-acid changes on canonical ENST00000375471 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PADI1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PADI1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Endometrial Carcinoma | 1/42 2% | 16/612 3% |
| Melanoma | 3/210 1% | 49/1899 3% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Retinoblastoma | 1/27 4% | 0/30 0% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 19/1390 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 12/810 1% |
| Other Solid Cancers | 3/94 3% | 21/1515 1% |
| Other Sarcomas | 1/69 1% | 9/699 1% |
| Colorectal Carcinoma | 6/143 4% | 35/3239 1% |
| Bladder Carcinoma | 2/58 3% | 10/956 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Ovarian Carcinoma | 6/109 6% | 3/998 0% |
| Biliary Tract Carcinoma | 1/54 2% | 7/950 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Esophageal Carcinoma | 0/23 0% | 6/769 1% |
| Gastric Carcinoma | 4/74 5% | 9/1809 0% |
| Ewings Sarcoma | 0/63 0% | 2/262 1% |
| Head and Neck Carcinoma | 4/85 5% | 6/1574 0% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 7/1592 0% |
| Neuroendocrine Tumour | 2/154 1% | 2/577 0% |
| Hepatocellular Carcinoma | 2/46 4% | 9/2210 0% |
| Prostate Carcinoma | 0/13 0% | 10/2105 0% |
| Cervical Carcinoma | 1/35 3% | 1/422 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 8/2534 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 8/2550 0% |
Mutation Distribution
Where PADI1 is mutated · all tissues, split by cell line vs tissue
How many mutations in PADI1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 374 mutations in PADI1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|